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Wednesday, July 11, 2007

Possible functions for Bree's Ribozymes?!?

According to Issac Gilman, these were possible functions of Bree's ribozyme

RNAse P related-tRNA synthesis
RNAse P is ribozyme which is cleaves the 5’ terminus of tRNA to give mature tRNA.
tRNA are involved in protein synthesis. Once the cell makes mRNA of the gene it wants the tRNA can ‘read’ the mRNA and transfer amino acids across so that they are in the correct order. The amino acids bind together to give a protein chain.

Splicsome related- intron/exon splicing
Splicosome is a ribozyme which cleaves introns out of the primary RNA to give the mature RNA (mRNA). Genes contain exons (sections which code for protein) and introns (junk). Before the mRNA can be read to make protein, these junk sequences (introns) need to be spliced out by the splicosome.

Hammerhead related: telomere synthesis
Telomeres are the end sections of chromosomes. Every time a cell replicates, it has to make another copy of all its chromosomes for the new cell. However every replication some of the telomere (end bits) are lost. Once all the telomeres are lost the cells stops dividing (hence we age etc). There is an enzyme which can make telomeres longer however it is inhibited by a ribozyme. It is thought hammerhead type ribozymes are responsible.

GlmS ribozyme related: fructose 6-phosphate pathway
GlmS is an enzyme which cleaves fructose 6-phosphate and glutamine to give glucosamine-6-phosphate which is important for metabolism. The mRNA of GlmS is a ribozyme. It can cleave itself. When GlmS is needed, the cell produces mRNA and this is made into the GlmS protein. However once there is enough GlmS, its own mRNA can cut itself up to stop its production.

Ref: GlmS glucosamine-6-phosphate activated ribozyme

  • More RNA/Ribozyme information on: Follow the RNA Today link on the right -->

    1. Thanks meeper! You are the best. I will add the link to this article to RNA Today for future reference:)

    2. Do we know which of these, if any is a hairpin ribozyme? I note that one is a hammerhead but there is nothing about hairpins.

    3. I don't think any of them are true hairpin ribozymes

      Although they may have hairpin structures in them

      RNAse P recognises tRNA which as 3 hairpins in its structure

    4. ..but tRNA its self is not a Ribozyme, right?

      Also, and explanation of "a regulatory hyper mutation" I think is in order" when you have time:)

    5. No tRNA is not a ribozyme

      I'll write something about the whole paper I think. Try to tie it in with what we already know.

      A regulatory hyper mutation is new to me, but I'm sure I can make up and explanation......I mean research it :)

    6. lol....well i think it probably just mean sequence that mutates more often than is statistically "normal", but yea see what you can find out, and I am definately looking forward to reading the next article.


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